Butyl chloroformate → HCID 53895456, compound

Participants

Reaction Steps

A solution of 40.0 g acetic acid 3-(4-tert-butyl-phenyl)-2- methyl-propenyl ester in 250 ml of THF was cooled to −70° C. A solution of 25.0 g potassium-tert-butoxide in 100 ml of THF was added at −70° C. during 35 min. and the resulting reaction mixture was stirred for 60 min. at the same temperature. 23.3 g butyl-chloroformate was dropped in during 40 min. and the reaction mixture was stirred for another 90 min. at −70° C. Then the reaction mixture was diluted with ether, washed with saturated NaHCO3 and brine. The organic phase was dried, filtered and evaporated to dryness. The residue was thin-layer distilled and purified by chromatography to yield a colorless oil.

Provenance & Evidence