Water → HCID 11761226, compound

HRID 1977571Notes

Reaction equation

HRID 1977571 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=1[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6].N1C=CC=CC=1.[CH:28]1([C:33](Cl)=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]1.O>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=1[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:33]([CH:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:34])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 78284Cyclopentanecarbonyl chlorideHCID 11066731HCID 11066731, compound

Product 1

HCID 11761226HCID 11761226, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.8 g (9 mmol) of 2-methoxy-N-(4-aminophenylsulfonyl)benzamide are suspended in 100 ml of dioxane, 0.72 g (9 mmol) of pyridine and 1.21 g (9 mmol) of cyclopentan-ecarbonyl chloride are added at 0° C., and the mixture is stirred for 2 hours at this temperature. The reaction mixture is subsequently transferred into water, and the resulting precipitate is filtered off with suction. After drying, 2.68 g (73%) of N—[4-(2-methoxy-benzoylsulfamoyl)phenyl]cyclopentanecarboxamide of melting point 202-206° C. are obtained.

Workup

  1. filtrationthe resulting precipitate is filtered off with suction
  2. customAfter drying

Sources & evidence

ORD record
ord-ca629d4bf0cf42c0a4d554deadc712af
Source dataset
uspto-grants-2001_05
Patent number
US06235680B1

Reaction notes

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