Hydrochloric Acid → 3-Cyclobutyl-D-alanine

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Reaction Steps

To 1.0 g (5 mmol) of methoxycarbonyl-3-cyclobutyl-D-alanine (Example 2, Step 2) 10 ml of 6M HCl is added and heated to reflux for 3 hours. The solution is evaporated at a pressure of 2.0-2.5 kPa, the residue is dissolved in 5 ml of water and evaporated to dryness and this process is repeated. The traces of water can be removed by azeotropic distillation with ethanol-benzene mixture. The residual oil is dissolved in 10 ml of ethanol and 5 mmol of 1,2-epoxy-propane is added. After cooling the precipitate is filtered off, the solid is washed with diethyl ether and dried.

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