2,4,5-Trichlorophenol → HCID 70100887, compound

Participants

Reaction Steps

11.3 g (28 mmol) of methoxycarbonyl-3-phenyl-D-alanine dicyclohexylammonium salt (Synthesis 2, Step A) is distributed between 75 ml of ethyl acetate and 30.5 ml of 1M KHSO4. The phases are separated, the organic phase is washed neutral with water, dried over anhydrous sodium sulphate and concentrated at a pressure of 2.0-2.5 kPa to a volume of 15 ml. To the cooled (approx. 0° C.) residue 5.5 g (28 mmol) of 2,4,5-trichlorophenol and 5,75 g (28 mmol) of dicyclohexyl carbodiimide are added and the reaction mixture is allowed to stand overnight. The separated dicyclohexylurea is filtered off, and the filtrate evaporated. The oily residue is crystallised from ethanol. The crystals are filtered, washed with diethyl ether and dried in a vacuum desiccator.

Provenance & Evidence