Methyl iodide → HCID 21994459, compound

Participants

Reaction Steps

A mixture of 5-(2-methoxyphenyl)-2-phenyl-3H-pyrimidin-4-one (0.4 g, example 9), methyl iodide (0.134 ml), potassium carbonate (0.398 g) and tetrabutylammonium bromide (0.048 g) in toluene (60 ml) and water (10 ml) was refluxed for 2 hours and then evaporated. The residue was taken up in diethyl ether and insolubles were filtered off. The ether solution was evaporated, and the residue was purified by flash chromatography on silica gel (eluent: n-hexane/ethyl acetate 6:4), to give the title compound in a pure form as a white solid (0.22 g).

Provenance & Evidence