Acetic Acid → HCID 135815263, compound

Participants

Reaction Steps

Glacial acetic acid (1.93 ml, 0.0337 mol) was added to N-{4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]-pyrimidin-5-yl)methyl]phenyl}acetamide (1.93 g, 0.0057 mol), followed by concentrated sulphuric acid (5.8 ml) and the mixture cooled in an ice-bath. Concentrated nitric acid (3.86 ml) was then added dropwise and once addition was complete, the reaction was stirred at room temperature for an hour.

Provenance & Evidence