Ammonia → HCID 135815261, compound

Participants

Reaction Steps

Concentrated sulphuric acid (10 ml) was added to N-{4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]phenyl}-(E)-3-ethoxy-2-propenamide (980 mg, 0.00248 mol) and the reaction stirred at room temperature for 4 hours. The mixture was then poured carefully onto ice and basified with 0.880 aqueous ammonia solution. The resulting precipitate was filtered and then triturated with boiling acetic acid/water to give the title compound (460 mg), m.p.>300° C.

Provenance & Evidence