1-Methylpiperazine → HCID 135815273, compound

Participants

Reaction Steps

N-methyl piperazine (1.28 ml, 0.0115 mol) was added to a solution of 4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]-1-benzenesulfonyl chloride (1.35 g, 0.0035 mol) in ethanol (20 ml) and the reaction stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure and the residue partitioned between dichloromethane (50 ml) and water (20 ml). The aqueous phase was extracted with further dichloromethane (50 ml), the combined organic extracts dried (MgSO4), filtered, and evaporated under reduced pressure.

Provenance & Evidence