HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(5-carbamoyl-1-methyl-3-propyl-1H-4-pyrazolyl)-2-(4-bromophenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzeneacetyl chloride, 4-bromo- | HCID 181552 | — |
| Reactant | 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide | HCID 3338044 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-carbamoyl-1-methyl-3-propyl-1H-4-pyrazolyl)-2-(4-bromophenyl)acetamide | HCID 21995144 | — |
Reaction Steps
A solution of this 4-bromophenylacetyl chloride in dry dichloromethane (5 ml) was then added dropwise to a solution of 4-amino-1-methyl-3-propyl-1H-5-pyrazolecarboxamide (6 g, 0.033 mol) and triethylamine (7 ml, 0.050 mol) in dichloromethane (250 ml), and the reaction stirred at room temperature for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235742B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-d31dd16d64d74f838797d36a24f98424 |
| Source note | uspto-grants-2001_05 |