Sodium Hydroxide → HCID 70052892, compound

HRID 1977644Notes

Reaction equation

HRID 1977644 reaction equation
[OH-].[Na+].C[O:4][C:5](=[O:22])[CH:6]([O:17][CH2:18][C:19](=[O:21])[NH2:20])[C:7]1[CH:12]=[CH:11][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:9][CH:8]=1>CO>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([CH:6]([O:17][CH2:18][C:19](=[O:21])[NH2:20])[C:5]([OH:22])=[O:4])=[CH:8][CH:9]=1)([CH3:16])([CH3:14])[CH3:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70051001HCID 70051001, compound

Product 1

HCID 70052892HCID 70052892, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1N aqueous sodium hydroxide solution (16 ml) was added to a solution of 4-tert-butyl carbamoylmethoxyphenylacetic acid methyl ester (2.8 g, 0.010 mol) in methanol (10 ml) and the reaction stirred at room temperature for 5 hours. The reaction mixture was then concentrated under reduced pressure, the residue suspended in 1N aqueous hydrochloric acid (20 ml) and extracted with diethyl ether (2×25 ml). The combined organic extracts were dried (MgSO4), filtered and evaporated under reduced pressure.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. extractionextracted with diethyl ether (2×25 ml)
  3. dry with materialThe combined organic extracts were dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-66828994d013497bb817ccbca3e4cf04
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

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