Acetonitrile → HCID 21995116, compound

HRID 1977645Notes

Reaction equation

HRID 1977645 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([C:10]1[N:14]([CH3:15])[N:13]=[C:12]([CH2:16][CH2:17][CH3:18])[C:11]=1[NH:19][C:20](=[O:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26](Br)=[CH:25]C=1)(=[O:9])[NH2:8].[C:31](#N)C>>[C:7]([C:10]1[N:14]([CH3:15])[N:13]=[C:12]([CH2:16][CH2:17][CH3:18])[C:11]=1[NH:19][C:20](=[O:30])[CH2:21][C:22]1[CH:23]=[CH:28][C:27]([CH2:31][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:26][CH:25]=1)(=[O:9])[NH2:8]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 8083MorpholineHCID 21995132HCID 21995132, compound

Product 1

HCID 21995116HCID 21995116, compound

Procedure

Morpholine (0.3 ml, 0.00344 mol) was added to a solution of N-(5-carbamoyl-1-methyl-3-propyl-1H-4-pyrazolyl)-2-(4-bromobenzyl)acetamide (400 mg, 0.001 mol) in acetonitrile (3 ml) and the reaction stirred at reflux for 2 hours. On cooling, the reaction was concentrated under reduced pressure.

Workup

  1. temperatureat reflux for 2 hours
  2. temperatureOn cooling
  3. concentrationthe reaction was concentrated under reduced pressure

Sources & evidence

ORD record
ord-04b9e1cb054144e6a4abb9851064e5ed
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

Loading…