HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilic Acid → N-Formylanthranilic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilic Acid | HCID 227 | — |
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Toluene | HCID 1140 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | N-Formylanthranilic acid | HCID 101399 | — |
Reaction Steps
A toluene (1100 ml) solution of anthranilic acid (205.5 g) and formic acid (170 ml) was heated under reflux for 4.5 hours. After the solution was allowed to cool, hexane was added to crystals deposited. The crystals were collected by filtration and washed with hexane. The resulting crystals were dried at 110° C. under reduced pressure to obtain N-formyl-anthranilic acid (244.0 g, crude product) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235730B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-ca4e60b87f72445bbc7632106119707b |
| Source note | uspto-grants-2001_05 |