Sodium Hydroxide → HCID 21995280, compound

HRID 1977684Notes

Reaction equation

HRID 1977684 reaction equation
C([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:20][C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=3)[N:15]=2)=[CH:9][CH:8]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:20][C:21]3[CH:22]=[C:23]([O:31][CH3:32])[C:24]([O:29][CH3:30])=[C:25]([O:27][CH3:28])[CH:26]=3)[N:15]=2)=[CH:11][CH:12]=1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21995173HCID 21995173, compound

Product 1

HCID 21995280HCID 21995280, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

The compound of Example 103 (250 mg, 0.57 mmol) in a solution of ethanol (10 ml) containing 6N aqueous NaOH (2.0 ml) was heated a reflux for 2 h. On cooling the ethanol was removed under reduced pressure and the basic solution brought to pH 5 with 2M hydrochloric acid. The resulting solution was concentrated under reduced pressure, and the residue taken up in hot ethanol (20 ml). This solution was filtered and the filtrate evaporated under reduced pressure to give a residue which was crystalised from ethanol to give the title compound (89 mg) as a white solid m.p. 144-150°. MS m/z 411 (M+H)+.

Workup

  1. temperaturewas heated
  2. temperaturea reflux for 2 h
  3. customwas removed under reduced pressure
  4. concentrationThe resulting solution was concentrated under reduced pressure
  5. filtrationThis solution was filtered
  6. customthe filtrate evaporated under reduced pressure
  7. customto give a residue which
  8. customwas crystalised from ethanol

Sources & evidence

ORD record
ord-a23b4981961e4b07982ff40c14e2d63a
Source dataset
uspto-grants-2001_05
Patent number
US06235746B1

Reaction notes

Loading…