3-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester → 3-(3-Butoxy-4-methoxyphenyl)-4,4-diethoxybutyric acid

HRID 1977698Notes

Reaction equation

HRID 1977698 reaction equation
C([O:3][C:4](=[O:32])[CH:5](C(OCC)=O)[CH:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:15]=1)[CH:7]([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10])C.C(OC(=O)C(C(OCC)=O)C(C1C=CC(OC)=C(OC)C=1)C(OCC)OCC)C>>[CH2:23]([O:22][C:16]1[CH:15]=[C:14]([CH:6]([CH:7]([O:8][CH2:9][CH3:10])[O:11][CH2:12][CH3:13])[CH2:5][C:4]([OH:32])=[O:3])[CH:19]=[CH:18][C:17]=1[O:20][CH3:21])[CH2:24][CH2:25][CH3:26]

Participants

3

Reactant 2

HCID 155213723-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl esterHCID 538277003-(3-Butoxy-4-methoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester

Product 1

HCID 219945283-(3-Butoxy-4-methoxyphenyl)-4,4-diethoxybutyric acidYield 47.5%

Procedure

Using the same procedure as in Example 1(3), 3-(3-butoxy-4-methoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester, instead of 3-(3,4-dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester, was used to obtain a yellow solid of the above-described compound via 3-(3-butoxy-4-methoxyphenyl)-4,4-diethoxybutyric acid (yield 47.5%).

Sources & evidence

ORD record
ord-509c8289fb994961969c6fa730b8de3a
Source dataset
uspto-grants-2001_05
Patent number
US06235739B1

Reaction notes

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