3-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester → HCID 21994529, compound

HRID 1977700Notes

Reaction equation

HRID 1977700 reaction equation
C([O:3][C:4](=[O:33])[CH:5](C(OCC)=O)[CH:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:15]=1)[CH:7]([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10])C.C(OC(=O)C(C(OCC)=O)C(C1C=CC(OC)=C(OC)C=1)C(OCC)OCC)C>>[CH3:26][C:24]([CH3:25])([CH3:27])[CH2:23][O:22][C:16]1[CH:15]=[C:14]([CH:6]([CH:7]([O:8][CH2:9][CH3:10])[O:11][CH2:12][CH3:13])[CH2:5][C:4]([OH:33])=[O:3])[CH:19]=[CH:18][C:17]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 155213723-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl esterHCID 69713045HCID 69713045, compound

Product 1

HCID 21994529HCID 21994529, compoundYield 68.7%

Procedure

Using the same procedure as in Example 1(3), 3-[3-(2,2-dimethylpropoxy)-4-methoxyphenyl]-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester, instead of 3-(3,4-dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester, was used to obtain a light yellow solid of the above-referenced compound via 3-[3-(2,2-dimethylpropoxy)-4-methoxyphenyl]-4,4-diethoxybutyric acid (yield 68.7%).

Sources & evidence

ORD record
ord-4f21d99f2efd4b428e90ab566339b95c
Source dataset
uspto-grants-2001_05
Patent number
US06235739B1

Reaction notes

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