3-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester → HCID 21994510, compound

HRID 1977701Notes

Reaction equation

C([O:3][C:4](=[O:38])[CH:5](C(OCC)=O)[CH:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH2:23][C:24]2([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:26][CH2:25]2)[CH:15]=1)[CH:7]([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10])C.C(OC(=O)C(C(OCC)=O)C(C1C=CC(OC)=C(OC)C=1)C(OCC)OCC)C>>[CH2:9]([O:8][CH:7]([O:11][CH2:12][CH3:13])[CH:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH2:23][C:24]2([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:25][CH2:26]2)[CH:15]=1)[CH2:5][C:4]([OH:38])=[O:3])[CH3:10]

Participants

Reactant 2

HCID 155213723-(3,4-Dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester

HCID 69712874HCID 69712874, compound

Product 1

HCID 21994510HCID 21994510, compoundYield 65.1%

Procedure

Using the same procedure as in Example 1(3), 4,4-diethoxy-2-ethoxycarbonyl-3-[4-methoxy-3-[(1-phenylcyclopropyl)methyloxy]phenyl]butyric acid ethyl ester, instead of 3-(3,4-dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester, was used to obtain a yellow solid of the above-described compound via 4,4-diethoxy-3-[4-methoxy-3-[(1-phenylcyclopropyl)methyloxy]phenyl]butyric acid (yield 65.1%).

Sources & evidence

ORD record: ord-9b318ae0c46b4c85a50515633ee1d58d
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235739B1

Reaction notes

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