MLS000756500 → 3-Amino-N-pyridin-3-ylbenzamide

HRID 1977739Notes

Reaction equation

HRID 1977739 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 1

HCID 308753MLS000756500

Product 1

HCID 121094833-Amino-N-pyridin-3-ylbenzamideYield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-(3-nitrobenzoylamino)-pyridine (2 g, 8.23 mmol) in ethanol (200 ml) was treated with 10% palladium on charcoal (0.5 g) and hydrogenated at atmospheric pressure for 4 h. Filtration and evaporation afforded the product as a white solid (1.51 g, 86%).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-dda6ea9e01e443e2a2bf3670799ac9e3
Source dataset
uspto-grants-2001_05
Patent number
US06235758B1

Reaction notes

Loading…