HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl carbamate → HCID 18005181, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl carbamate | HCID 69322 | — |
| Reactant | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| Reactant | HCID 18005195 | HCID 18005195 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18005181 | HCID 18005181 | 13% |
Reaction Steps
5-Amino-2-(pyridin-4-ylmethyloxy)pyridine (0.5 g, 2.5 mmol) was converted to the phenyl carbamate and treated with 5-methoxy-6-trifluoromethylindoline (0.54 g, 2.5 mmol) as in the method of Example 52. Chromatography using ethyl acetate as eluant followed by recrystallisation from ethyl acetate/petroleum ether (60-80°) afforded the title compound (0.13 g, 13%) as an off-white solid m.p. 187-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235758B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-11effff5b1074c308abc341b9039fc67 |
| Source note | uspto-grants-2001_05 |