HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1977807Generated: November 1, 2026
Hydrochloric Acid → 2-(Piperidin-4-yl)benzonitrile hydrochloride
https://huagongshe.com/reaction/1977807
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-cyanophenyl)piperidine-1-carboxylate | HCID 18326585 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(Piperidin-4-yl)benzonitrile hydrochloride | HCID 18326627 | — |
Reaction Steps
To a solution of 2-(1-tertbutoxycarbonylpiperidin-4-yl)benzonitrile (1.7 g, 5.9 mmol) in ethyl acetate (˜50 ml), cooled to 0° C. was added hydrogen chloride gas, bubbled vigorously for 5 minutes. The reaction mixture was stirred for 10 minutes at 0° C., purged with argon and concentrated. Flushing with ethyl acetate×3 and concentration gave 2-(piperidin-4-yl) benzonitrile hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06235759B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-e5c3211e59ad4b079c4a38205ab9cf6e |
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| Source note | uspto-grants-2001_05 |
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