反应详情

236 mg of 2-bromo-1-oxoindane-5-carbonitrile are dissolved in 10 ml of acetone and, at 0° C., 135 mg of N-methylthiourea are added. The mixture is stirred at room temperature for 3 h and at ice-bath temperature for 90 minutes. The precipitate is filtered off with suction, washed with acetone and dried in vacuo. The hydrobromide of 3a-hydroxy-2-methylamino-8,8a-dihydro-3aH-indeno[1,2-d]thiazole-6-carbonitrile is obtained with a melting point of 287-288° C.

1. filtrationThe precipitate is filtered off with suction
2. washwashed with acetone
3. customdried in vacuo