Thiourea → HCID 21995594, compound

HRID 1977819Notes

Reaction equation

HRID 1977819 reaction equation
[Br:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][C:6]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)=[CH:7][CH:8]=2)[C:3]1=[O:21].[NH2:22][C:23]([NH2:25])=[S:24]>CC(C)=O>[BrH:1].[NH2:25][C:23]1[S:24][CH:2]2[CH2:10][C:9]3[CH:8]=[CH:7][C:6]([C:11]4[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=4)=[CH:5][C:4]=3[C:3]2([OH:21])[N:22]=1.[NH2:25][C:23]1[S:24][CH:2]2[CH2:10][C:9]3[CH:8]=[CH:7][C:6]([C:11]4[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=4)=[CH:5][C:4]=3[C:3]2([OH:21])[N:22]=1

Participants

5

Reactant 2

HCID 2723790ThioureaHCID 21702068HCID 21702068, compound

Product 2

HCID 21995594HCID 21995594, compoundHCID 21995613HCID 21995613, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1.06 g of 2-bromo-6-(4-trifluoromethylphenyl)indan-1-one are dissolved with 266 mg of thiourea in 10 ml of dry acetone and stirred at ice-bath temperature for 4 h. The precipitate is filtered off with suction, washed with acetone and dried in vacuo. The hydrobromide of 2-amino-5-(4-trifluoromethylphenyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol is obtained with a melting point of 228-230° C.

Workup

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with acetone
  3. customdried in vacuo

Sources & evidence

ORD record
ord-bcee8c91978942e7b091bac73cb36e5d
Source dataset
uspto-grants-2001_05
Patent number
US06235763B1

Reaction notes

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