反应详情

5.5 g of N′-(5-chloro-2-methylindan-1-ylidene)-N,N-dimethylhydrazine are emulsified in 100 ml of 2N sulfuric acid and boiled under reflux for 4 h. The cooled reaction mixture is cautiously extracted with ethyl acetate; the organic extract is extracted several times with saturated sodium bicarbonate solution, dried over sodium sulfate, filtered, dried in vacuo and chromatographed on silica gel with ethyl acetate/hetpane ⅕. 5-Chloro-2-methylindan-1-one is obtained as an oil.

1. temperatureunder reflux for 4 h
2. customThe cooled reaction mixture
3. extractionis cautiously extracted with ethyl acetate
4. extractionthe organic extract
5. extractionis extracted several times with saturated sodium bicarbonate solution
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customdried in vacuo
9. customchromatographed on silica gel with ethyl acetate/hetpane ⅕