Thiourea → HCID 21995611, compound

HRID 1977823Notes

Reaction equation

HRID 1977823 reaction equation
[Br:1][C:2]1([CH3:13])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:11])[CH:8]=2)[C:3]1=[O:12].[NH2:14][C:15]([NH2:17])=[S:16]>>[BrH:1].[NH2:17][C:15]1[S:16][C:2]2([CH3:13])[CH2:10][C:9]3[CH:8]=[C:7]([Cl:11])[CH:6]=[CH:5][C:4]=3[C:3]2([OH:12])[N:14]=1

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 21995598HCID 21995598, compound

Product 1

HCID 21995611HCID 21995611, compound

Procedure

1.5 g of 2-bromo-5-chloro-2-methylindan-1-one are dissolved together with 460 mg of thiourea in 50 ml of triacetone and boiled under reflux for 8 h. The precipitate is filtered off with suction, washed with acetone and dried in vacuo. 2-Amino-6-chloro-8a-methyl-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol hydrobromide is obtained and melts at 229° C. with decomposition.

Workup

  1. temperatureunder reflux for 8 h
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with acetone
  4. customdried in vacuo

Sources & evidence

ORD record
ord-391adb65afab4586b252414538a60ac6
Source dataset
uspto-grants-2001_05
Patent number
US06235763B1

Reaction notes

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