Triethylamine → HCID 57189351, compound

Participants

Reaction Conditions

Reaction Steps

263 mg of 5-chloro-2-bromo-2-fluoroindan-1-one and 152 mg of thiourea are dissolved in 2.5 ml of dry dimethyl sulfoxide and stirred at 50° C. for 8 h. Excess triethylamine is added to the reaction mixture, which is then concentrated in vacuo. The residue is purified by chromatography on silica gel with ethyl acetate as eluent. 2-Amino-6-chloro-8a-fluoro-8 ,8a-dihydroindeno[1,2-d]thiazol-3a-ol is obtained with a melting point of 159° C.

Provenance & Evidence