2-(4-(4-Aminobutyl)piperazin-1-yl)ethan-1-ol → 5-(3-{4-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-butyl}-ureido)-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amide

HRID 1977886Notes

Reaction equation

HRID 1977886 reaction equation
C1(O[C:8](=[O:30])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[C:11]=2[C:27](=[O:29])[NH2:28])C=CC=CC=1.[NH2:31][CH2:32][CH2:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][N:39]([CH2:42][CH2:43][OH:44])[CH2:38][CH2:37]1>>[OH:44][CH2:43][CH2:42][N:39]1[CH2:40][CH2:41][N:36]([CH2:35][CH2:34][CH2:33][CH2:32][NH:31][C:8](=[O:30])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[C:11]=2[C:27]([NH2:28])=[O:29])[CH2:37][CH2:38]1

Participants

3

Reactant 2

HCID 71384322-(4-(4-Aminobutyl)piperazin-1-yl)ethan-1-olHCID 54053016[4-Carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester

Product 1

HCID 100531235-(3-{4-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-butyl}-ureido)-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amide

Procedure

The title compound was prepared from [4-carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 2-[4-(4-amino-butyl)-piperazin-1-yl]-ethanol by the procedure analogous to Example 1. MS (APCI, m/z): 545 [M+H]+.

Sources & evidence

ORD record
ord-266c2410f7614311ae1ee27ab8bf9af5
Source dataset
uspto-grants-2001_05
Patent number
US06235764B1

Reaction notes

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