2-(2-Aminoethyl)-1-methylpyrrolidine → 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-{3-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-ureido}-isothiazole-4-carboxylic Acid Amide

HRID 1977889Notes

Reaction equation

HRID 1977889 reaction equation
C1(O[C:8](=[O:29])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=3[F:25])[C:11]=2[C:26](=[O:28])[NH2:27])C=CC=CC=1.[CH3:30][N:31]1[CH2:35][CH2:34][CH2:33][CH:32]1[CH2:36][CH2:37][NH2:38]>>[F:23][C:22]1[CH:21]=[C:20]([CH3:24])[CH:19]=[C:18]([F:25])[C:17]=1[CH2:16][O:15][C:12]1[C:11]([C:26]([NH2:27])=[O:28])=[C:10]([NH:9][C:8]([NH:38][CH2:37][CH2:36][CH:32]2[CH2:33][CH2:34][CH2:35][N:31]2[CH3:30])=[O:29])[S:14][N:13]=1

Participants

3

Reactant 2

HCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 11384589(4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester

Product 1

HCID 104790753-(2,6-Difluoro-4-methyl-benzyloxy)-5-{3-[2-(1-methyl-pyrrolidin-2-yl)-ethyl]-ureido}-isothiazole-4-carboxylic Acid Amide

Procedure

The title compound was prepared from [4-carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 2-(1-methyl-pyrrolidin-2-yl)-ethylamine by the procedure analogous to Example 1. MS (APCI, m/z): 454 [M+H]+.

Sources & evidence

ORD record
ord-07db1df05a7f495eb7c644e4b14b3744
Source dataset
uspto-grants-2001_05
Patent number
US06235764B1

Reaction notes

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