(4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester → HCID 11634747, compound

HRID 1977896Notes

Reaction equation

HRID 1977896 reaction equation
C1(O[C:8](=[O:29])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=3[F:25])[C:11]=2[C:26](=[O:28])[NH2:27])C=CC=CC=1.[NH2:30][CH2:31][CH2:32][CH2:33][CH2:34][N:35]([CH2:39][CH2:40][OH:41])[CH2:36][CH2:37][OH:38]>>[OH:41][CH2:40][CH2:39][N:35]([CH2:36][CH2:37][OH:38])[CH2:34][CH2:33][CH2:32][CH2:31][NH:30][C:8](=[O:29])[NH:9][C:10]1[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]2[C:18]([F:25])=[CH:19][C:20]([CH3:24])=[CH:21][C:22]=2[F:23])[C:11]=1[C:26]([NH2:27])=[O:28]

Participants

3

Reactant 2

HCID 11384589(4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl esterHCID 21972006HCID 21972006, compound

Product 1

HCID 11634747HCID 11634747, compound

Procedure

The title compound was prepared from [4-carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 2-[(4-amino-butyl)-(2-hydroxy-ethyl)-amino]-ethanol by the procedure analogous to Example 1. MS (APCI, m/z): 502 [M+H]+.

Sources & evidence

ORD record
ord-975fb52d17cc4f2183a152096cf50a75
Source dataset
uspto-grants-2001_05
Patent number
US06235764B1

Reaction notes

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