4-Bromo-1-(bromomethyl)-2-chlorobenzene → 4-Chloro-1-[(4-bromo-2-chlorophenyl)methyl]-5-formyl-2-phenyl-imidazole

HRID 1977898Notes

Reaction equation

HRID 1977898 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:5][C:6]=1[CH:7]=[O:8].[Br:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Br)=[C:18]([Cl:24])[CH:17]=1>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:5]([CH2:20][C:19]2[CH:22]=[CH:23][C:16]([Br:15])=[CH:17][C:18]=2[Cl:24])[C:6]=1[CH:7]=[O:8]

Participants

3

Reactant 2

HCID 219144864-Bromo-1-(bromomethyl)-2-chlorobenzeneHCID 178520008HCID 178520008, compound2×

Product 1

HCID 184000794-Chloro-1-[(4-bromo-2-chlorophenyl)methyl]-5-formyl-2-phenyl-imidazole

Procedure

The title compound was prepared by reaction of 4-chloro-5-formyl-2-phenylimidazole with 4-bromo-2-chlorobenzyl bromide according to the process mentioned in Example 1a). In this case, starting from 2.0 g (9.68 mmol) of 4-chloro-5-formyl-2-phenylimidazole, 2.6 g of the title compound was obtained.

Sources & evidence

ORD record
ord-f709d5e63bb1410cae058854e59bd4f2
Source dataset
uspto-grants-2001_05
Patent number
US06235766B1

Reaction notes

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