3,4-Dimethoxybenzyl bromide → HCID 54375419, compound

HRID 1977913Notes

Reaction equation

HRID 1977913 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH2:6]Br.[NH:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[N:30]=[C:29]([NH2:31])[CH:28]=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[CH2:15][CH2:14]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH2:6][N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]3[N:30]=[C:29]([NH2:31])[CH:28]=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 109004583,4-Dimethoxybenzyl bromideHCID 21995458HCID 21995458, compound

Product 1

HCID 54375419HCID 54375419, compound

Procedure

Prepared from Example 13, using 3,4-dimethoxybenzyl bromide to alkylate 6-[4-(piperidin-4-yl)-phenyl]-pyridin-2-ylamine, in 89%, mp 150-165° C. as the hydrochloride salt.

Workup

  1. customPrepared from Example 13

Sources & evidence

ORD record
ord-637a52febed84314a97f0e20dd563520
Source dataset
uspto-grants-2001_05
Patent number
US06235750B1

Reaction notes

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