1,3-Benzodioxole, 5-(bromomethyl)- → HCID 12082728, compound

HRID 1977914Notes

Reaction equation

HRID 1977914 reaction equation
[CH2:1]1[O:11][C:10]2[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][C:3]=2[O:2]1.[NH:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[N:29]=[C:28]([NH2:30])[CH:27]=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1>>[CH2:1]1[O:11][C:10]2[CH:9]=[CH:8][C:5]([CH2:6][N:12]3[CH2:17][CH2:16][CH:15]([C:18]4[CH:19]=[CH:20][C:21]([C:24]5[N:29]=[C:28]([NH2:30])[CH:27]=[CH:26][CH:25]=5)=[CH:22][CH:23]=4)[CH2:14][CH2:13]3)=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 64514231,3-Benzodioxole, 5-(bromomethyl)-HCID 21995458HCID 21995458, compound

Product 1

HCID 12082728HCID 12082728, compound

Procedure

Prepared from Example 13, using 3,4-methylenedioxybenzyl bromide to alkylate 6-[4-(piperidin-4-yl)-phenyl]-pyridin-2-ylamine, in 82%, mp 150-165° C. as the hydrochloride salt.

Workup

  1. customPrepared from Example 13

Sources & evidence

ORD record
ord-0e468034b1234da29bc815eb577efd69
Source dataset
uspto-grants-2001_05
Patent number
US06235750B1

Reaction notes

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