反应详情

A solution of 6.985 g 1-benzyloxy-2-tert-butyl-4-methyl-benzene (27 mmol) and 115 g ammoniumcer (IV)-nitrate in 1000 ml acetic acid (50% v/v) was stirred at 90° C. for one hour. After cooling down to RT, the reaction mixture was extracted with AcOEt/heptane 1:9, dried over magnesium sulfate, filtered off and concentrated under vacuo. The residue was purified by flash column chromatography (heptane/AcOEt 95/5 to 90/10) to give 3.48 g of an orange solid. MS (ISP) 269.3 (M+H)+.

1. extractionthe reaction mixture was extracted with AcOEt/heptane 1:9
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered off
4. concentrationconcentrated under vacuo
5. customThe residue was purified by flash column chromatography (heptane/AcOEt 95/5 to 90/10)