Chloroform → HCID 53693471, compound

Participants

Reaction Steps

To a suspension of (S)-1-(2-aminoethyl)-6-methoxyindan hydrochloride (0.10 g, 0.44 mmol) and triethylamine (61 μl, 0.44 mmol) in acetonitrile (3 ml) was added ethyl isocyanate (35 μl, 0.44 mmol). The mixture was stirred for 30 min at room temperature, then diluted with water and the product was extracted with ethyl acetate. The extract was washed with 1N hydrochloric acid and brine, dried over anhydrous magnesium sulfate, and the solvent was removed in vacuo. The residue was recrystallized from ethyl acetate and isopropyl ether to afford the titled compound (79 mg, yield 69%), m.p. 104-105° C. [α]Hg365 +48.80 (c 0.5, CHCl3)

Provenance & Evidence