Sodium Bicarbonate → HCID 70231053, compound

Participants

Reaction Conditions

Reaction Steps

A 0° C. suspension of Example 126C (1.34 g, 2.79 mmol) in a 2:1 mixture of methanol/ water (60 mL) was treated with oxone (4.28 g, 6.97 mmol) and NaHCO3 (0.58 g, 6.97 mmol), stirred at 0° C. for 1 hour, and then at room temperature for 18 hours. The suspension was diluted with water then extracted with ethyl acetate (3×30 mL). The combined extracts were washed with water, brine, dried, filtered, concentrated and purified on silica gel by flash column chromatography eluting with 1 to 2 hexanes/ethyl acetate to give 1.2 g of the desired product.

Provenance & Evidence