HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → HCID 21995410, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Reactant | HCID 15714114 | HCID 15714114 | — |
| Reactant | HCID 54201341 | HCID 54201341 | — |
| Reactant | HCID 131722572 | HCID 131722572 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21995410 | HCID 21995410 | 75% |
Reaction Steps
Prepared as in Example 112, using 4-t-butoxycarbonylamino-2,6-dimethylpiperidine coupling with 2-(2,5-dimethylpyrrolyl)-6-(4-(carboxymethyl)phenyl)-pyridin in 75% yield, followed by reduction with borane methyl sulfide in refluxing tetrahydrofuran in 17% yield, followed by deprotection using hydroxylamine hydrochloride in refluxing ethanol in 85% yield, as a hygroscopic solid as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235747B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-51e841a0d0074f45af0dc48464d92b38 |
| Source note | uspto-grants-2001_05 |