HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexylpiperazine → HCID 18414476, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexylpiperazine | HCID 87298 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Reactant | HCID 54201341 | HCID 54201341 | — |
| Reactant | HCID 131722572 | HCID 131722572 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18414476 | HCID 18414476 | 100% |
Reaction Steps
Prepared as in Example 112, using N-cyclohexylpiperazine coupling with 2-(2,5-dimethylpyrrolyl)-6-(4-(carboxymethyl)phenyl)-pyridine in 100% yield followed by reduction using borane methyl sulfide in refluxing tetrahydrofuran in 97% yield, then deprotection using hydroxylamine hydrochloride in refluxing ethanol in 98% yield, as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235747B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-2729e11460ba4ad2b10aede5ffd837ac |
| Source note | uspto-grants-2001_05 |