HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amantadine → HCID 18414489, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amantadine | HCID 2130 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Reactant | HCID 54201341 | HCID 54201341 | — |
| Reactant | HCID 131722572 | HCID 131722572 | — |
| Product | HCID 18414489 | HCID 18414489 | 89.5% |
Reaction Steps
Preparedas in Example 112, using 1-aminoadamantane for the coupling with 2-(2,5-dimethylpyrrolyl)-6-(4-(carboxymethyl)phenyl)-pyridine followed by deblocking with hydroxylamine hydrochloride and borane methyl sulfide reduction in 89.5% yield, mp 200-220° C. (dec.) as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235747B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-3ae96c0e7ac848c5918aa6eef265b877 |
| Source note | uspto-grants-2001_05 |