HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 21995379, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 54394888 | HCID 54394888 | — |
| Reactant | HCID 131722572 | HCID 131722572 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21995379 | HCID 21995379 | 43% |
Reaction Steps
Prepared from (6-(4-formylphenyl)2-(2,5-dimethylpyrrolyl)-pyridine (Example 112), using N-methylpiperazine with sodium cyanoborohydride in methanol in 43% yield, followed by deblocking using hydroxylamine hydrochloride in refluxing ethanol in 78% yield, mp 240-250° C. (dec.) as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235747B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-1aa26a3d8ee14e64b5c799b199e88f85 |
| Source note | uspto-grants-2001_05 |