Nitrogen → HCID 18414393, compound

Participants

Reaction Steps

To a 100 mL three-necked round-bottomed flask equipped with septum and N2 inlet were added 165 mg (0.345 mmol) 2-(2,5-dimethylpyrrol-1-yl)-4-methyl-6-(4-(2-(phenethylpiperazin-4-yl)ethyl)phenyl)-pyridine, 120 mg (1.726 mmol) hydroxylamine hydrochloride, 1 mL water, and 5 mL ethanol. The reaction was refluxed 14 hr, cooled, evaporated, and taken up in ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate, and evaporated. The residue was chromatographed on silica gel usirg methanol/methylene chloride as eluant to afford an oil, which was converted to thie hydrochloride salt using 1 N HCl in ether to give 18 mg (10%), mp 242-250° C.

Provenance & Evidence