4-Methoxybenzyl bromide → HCID 86756716, compound

HRID 1978055Notes

Reaction equation

O1CCCCC1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:39][CH:40]([CH3:42])[CH3:41])[C:22]([NH:24][N:25]([S:35]([CH3:38])(=[O:37])=[O:36])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].COC1C=CC(CBr)=CC=1>>[OH:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:39][CH:40]([CH3:42])[CH3:41])[C:22]([NH:24][N:25]([S:35]([CH3:38])(=[O:37])=[O:36])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:10]

Participants

Reactant 2

HCID 1650214-Methoxybenzyl bromide

HCID 86756717HCID 86756717, compound

Product 1

HCID 86756716HCID 86756716, compound

Procedure

The (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-2′-(4-methoxybenzyl)-4-methylvalerohydrazide used as the starting material was prepared in an analogous manner to that described in Example 15, part (iii), starting from (E)-(2R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesuophonyl)-4-methylvalerohydrazide by reaction with 4-methoxybenzyl bromide.

Workup

customwas prepared in an analogous manner to that

Sources & evidence

ORD record: ord-07217351126146a99a3487d6441b07e4
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235787B1

Reaction notes

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