4-Nitrobenzyl bromide → HCID 86756721, compound

HRID 1978057Notes

Reaction equation

HRID 1978057 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:40][CH:41]([CH3:43])[CH3:42])[C:22]([NH:24][N:25]([S:36]([CH3:39])(=[O:38])=[O:37])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([N+:33]([O-:35])=[O:34])=[CH:29][CH:28]=1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].O1CCCCC1ONC([C@H]([C@@H](CC(C)C)C(NNS(C)(=O)=O)=O)C/C=C/C1C=CC=CC=1)=O.[N+](C1C=CC(CBr)=CC=1)([O-])=O>>[OH:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:40][CH:41]([CH3:43])[CH3:42])[C:22]([NH:24][N:25]([S:36]([CH3:39])(=[O:37])=[O:38])[CH2:26][C:27]1[CH:28]=[CH:29][C:30]([N+:33]([O-:35])=[O:34])=[CH:31][CH:32]=1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10]

Participants

4

Reactant 3

HCID 660114-Nitrobenzyl bromideHCID 86756722HCID 86756722, compoundHCID 86756723HCID 86756723, compound

Product 1

HCID 86756721HCID 86756721, compound

Procedure

The (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-(4-nitrobenzyl)valerohydrazide used as the starting material was prepared in an analogous manner to that described in Example 15, part (iii), starting from (E)-(2R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methylvalerohydrazide by reaction with 4-nitrobenzyl bromide.

Workup

  1. customwas prepared in an analogous manner to that

Sources & evidence

ORD record
ord-b02066b048f44a248db661740f7823fd
Source dataset
uspto-grants-2001_05
Patent number
US06235787B1

Reaction notes

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