1-Bromomethyl-2,6-dichlorobenzene → HCID 86756743, compound

HRID 1978077Notes

Reaction equation

HRID 1978077 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:22]([NH:24][NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].[Cl:34][C:35]1[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[C:36]=1[CH2:37]Br>>[Cl:34][C:35]1[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[C:36]=1[CH2:37][N:25]([S:26]([CH3:29])(=[O:28])=[O:27])[NH:24][C:22](=[O:23])[C@@H:21]([C@@H:11]([C:9](=[O:10])[NH:8][OH:7])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:30][CH:31]([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 301591-Bromomethyl-2,6-dichlorobenzeneHCID 86756723HCID 86756723, compound

Product 1

HCID 86756743HCID 86756743, compound

Procedure

The starting material was prepared in an analogous manner to that described in Example 15, part (iii), starting from (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methylvalerohydrazide and 2,6-dichlorobenzyl bromide.

Workup

  1. customThe starting material was prepared in an analogous manner to that

Sources & evidence

ORD record
ord-0dd28088bdd443a280dda9747acff0e4
Source dataset
uspto-grants-2001_05
Patent number
US06235787B1

Reaction notes

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