HCID 86756759, compound → HCID 86756758, compound

Participants

Reaction Steps

In an analogous manner to that described in the first paragraph of Example 45, starting from 0.357 g of a mixture of 2(R)-[(S)-(cyclopentyl)[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]methyl]-2′-isobutyl-2′-(methanesulphonyl)-4-methylvalerohydrazide and 2(R)-[(S)-(cyclopentyl)[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]methyl]-2′-isobutyl-2′-(methanesulphonyl)-4-methyl-3-pentenohydrazide there was obtained 0.219 g of a mixture of 2(R)-[(S)-(cyclopenyl)(hydroxycarbamoyl)methyl]-2′-isobutyl-2′-(methanesulphonyl-4-methyl-3-pentenohydrazide (compound A) and 2(R)-[(S)-(cyclopentyl)hydroxycarbamoyl)methyl]-2′-isobutyl-2′-(methanesulphonyl)-4-methyl-3-pentenohydrazide (compound B) in the form of a white solid. The compounds were then separated by preparative high-performance liquid chromatography on a DYNAMAX 5 mm C18 300A column with dimensions of 21.4×50 mm using the gradient elution method specified below:

Provenance & Evidence