Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cefuroxime Axetil | HCID 6321416 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Cefuroxime | HCID 5479529 | 89.6% |
Reaction Steps
Cefuroxime axetil (20.4 gm, S-isomer >90%, R-isomer <10%) was dissolved in a mixture of tetrahydrofuran (204 ml) and methanol (39 ml). This clear solution was cooled to -60° C., and sodium methoxide (5 gm) was added. The reaction mixture was stirred at −55 to −60° C. for 1 hour. Hydrochloric acid was added and the procedure described in Example 2 was followed to obtain cefuroxime (15.19 gm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06235896B1 |
|---|
| Source dataset | uspto-grants-2001_05 |
|---|
| ORD ID | ord-d27649a47b7542cba92a3e672df07ed3 |
|---|
| Source note | uspto-grants-2001_05 |
|---|
