反应详情

温度

-2.5 °C

2.7 g (0.015 mol) of 30% strength sodium methylate were added over the course of 15 minutes to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol while stirring at −5 to 0° C. The reaction mixture was stirred at 0° C. for 1 hour, warmed to 25° C. and then concentrated under reduced pressure, stirred with water and extracted 2× with methylene chloride. Drying and concentrating under reduced pressure resulted in 3.1 g (98% of theory) of the title compound of nD25=1.4770.

1. stirringThe reaction mixture was stirred at 0° C. for 1 hour
2. temperaturewarmed to 25° C.
3. concentrationconcentrated under reduced pressure
4. stirringstirred with water
5. extractionextracted 2× with methylene chloride
6. customDrying
7. concentrationconcentrating under reduced pressure