Dimethylamine → HCID 86747119, compound

Participants

Reaction Conditions

Reaction Steps

1.9 g (0.0417 mol) of gaseous dimethylamine were passed over the course of 10 minutes into a stirred mixture of 8.9 g (0.0417 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine and 100 ml of tetrahydrofuran at 0° C. The mixture was stirred at 0° C. for 1 hour and at 25° C. for 2 hours and worked up as usual, resulting in 9.7 g (97.5% of theory) of the title compound of melting point 127-130° C.

Provenance & Evidence