HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 2,4-Imidazolidinedione, 5-cyclohexyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | Lithium Bromide | HCID 82050 | — |
| Catalyst | Palladium bromide (PdBr2) | HCID 83469 | — |
| Product | 2,4-Imidazolidinedione, 5-cyclohexyl- | HCID 3870843 | 70% |
Reaction Steps
2,800 g cyclohexanecarbaldehyde, 1,500 g urea, 25 ml N-methylpyrrolidone, 0.017 g palladium(II) bromide, 0.033 g triphenylphosphane, 0.100 g sulfuric acid and 0.760 g lithium bromide are reacted in a 300 ml autoclave under 60 bar at 100C. After a reaction time of 12 hours, the solvent is removed in vacuo and the residue is analyzed by means of high pressure liquid chromatography (HPLC). 3,200 g 5-cyclohexyl-hydantoin are formed. This corresponds to a yield of 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235910B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-580fcdc3935949378a5ba7b115ad5962 |
| Source note | uspto-grants-2001_05 |