HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl cyanoacetate → Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Perfluoropropionyl chloride | HCID 67911 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate | HCID 86756713 | — |
Reaction Steps
To 20 ml of tetrahydrofuran, 3.39 g (30 mmol) of ethyl cyanoacetate and 6.06 g (60 mmol) of triethylamine were dissolved and stirred at room temperature. Successively, 5.47 g (30 mmol) of pentafluoropropionyl chloride was dropwise added and stirred for 5 hours at room temperature. However, formation of desired product could not be confirmed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235911B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-5ebf959e1e1d4832bd243770b69d9c26 |
| Source note | uspto-grants-2001_05 |