HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Fluoro-2-(trifluoromethyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzoic acid | HCID 688255 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Fluoro-2-(trifluoromethyl)benzoyl chloride | HCID 605680 | — |
Reaction Steps
A suspension of 2-trifluoromethyl-4-fluorobenzoic acid (16.85 g, 81 mmol) in dichloromethane (150 mL) containing a few drops of dimethylformamide was treated dropwise under nitrogen with oxalyl chloride (8.5 mL, 97.4 mmol). After the gas evolution subsided, the reaction mixture was refluxed for an additional 10 minutes, and then evaporated to dryness in vacuo. The crude acid chloride was used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235900B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-f1f786b53c1e443ba771a2b5f71fdd54 |
| Source note | uspto-grants-2001_05 |