反应详情

Sodium hydride (60% suspension in oil, 3.85 g, 96.3 mmol) was washed with hexane, dried under nitrogen and resuspended in dry dimethylformamide (150 mL). A solution of 3-methylpyrazole (7.75 mL, 96.3 mmol) in dimethylformamide (50 mL) was added dropwise at ambient temperature. Stirring was continued until the gas evolution subsided, and then a solution of methyl 4-fluoro-2-trifluoromethylbenzoic acid methyl ester of Step A (17.8 g, 80.1 mmol) in dimethylformamide (50 mL) was added dropwise to the clear solution. After stirring for 30 min at room temperature, the reaction was quenched with saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic extracts were dried over sodium sulfate and evaporated to dryness. The residue was dissolved in 1:1 mixture of dichloromethane and hexane and absorbed onto a silica Merck-60 flash column. Elution with a dichloromethane-hexane gradient (from 1:1 to 4:1) provided the title compound (13.6 g) as a white solid, m.p. 59-61° C.

1. customdried under nitrogen
2. stirringAfter stirring for 30 min at room temperature
3. customthe reaction was quenched with saturated aqueous ammonium chloride
4. extractionextracted with ethyl acetate
5. dry with materialThe organic extracts were dried over sodium sulfate
6. customevaporated to dryness
7. dissolutionThe residue was dissolved in 1:1 mixture of dichloromethane and hexane
8. customabsorbed onto a silica Merck-60 flash column
9. washElution with a dichloromethane-hexane gradient (from 1:1 to 4:1)