反应详情

To a solution of 4-(3-methyl-1H-pyrazol-1-yl)-2-trifluoromethyl benzoic acid methyl ester of Step B (1.19 g, 4.2 mmol) in methanol (10 mL) was added 2.5 N sodium hydroxide (3.3 mL, 8.3 mmol). The mixture was heated at reflux for 90 minutes, cooled and concentrated. The residue was partitioned between ethyl acetate and 1N hydrochloric acid. The organic extracts were dried over sodium sulfate and evaporated to dryness to give the title compound (1.14 g) as a white solid, m.p. 192-194° C.

1. temperatureThe mixture was heated
2. temperatureat reflux for 90 minutes
3. temperaturecooled
4. concentrationconcentrated
5. customThe residue was partitioned between ethyl acetate and 1N hydrochloric acid
6. dry with materialThe organic extracts were dried over sodium sulfate
7. customevaporated to dryness